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ГЕРОНТОЛОГИЯ
«GERONTOLOGY» Scientific Journal

БИОГЕРОНТОЛОГИЯ

THE ROLE OF MITOCHONDRIES IN CELL SENESCENCE

Ivko O.M.1
1. Saint Petersburg Institute of Bioregulation and Gerontology, Saint Petersburg
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Summary:
The review describes the main molecular and cellular aspects of aging, which is connected with mitochondrial dysfunction. The base mitochondrial function is to obtain the reach of energy substrates and its oxidative degradation with synthesis of СО2 and Н2О This process is matched with ATP synthesis. One of the сconsequence of mitochondrial degradation during cell senescence, in addition to active forms of oxygen synthesis, is the release of mitochondrial DNA (mtDNA). The level of mtDNA in blood plasma increases after 50 years old and correlates with the pro-inflammation cytokines concentration. This is one of the reason of the moderate inflammation response, which releases during aging (inflamm-aging). DAMPs (damage-associated molecular pattern) penetrate from mitochondries into the blood during cell apoptosis. DAMPs promote the development of many inflammation diseases: sepsis, syndrome of system inflammation response, tissue ischemic destruction.
Keywords mitochondries, aging, inflamm-aging, apoptosis

Bibliographic reference:
Ivko O.M., THE ROLE OF MITOCHONDRIES IN CELL SENESCENCE // «GERONTOLOGY» Scientific Journal. - 2020. - №4;
URL: http://gerontology.su/magazines?textEn=322 (date of access: 15.08.2022).

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