Электронный научный журнал

In patients of senile age there is an increase in platelet aggregation activity, an increase in blood viscosity, a violation of the functional state of the endothelium, which leads to the development of IHD, and also causes the severity of the course and the prognosis of the disease. Also, in most patients with atherosclerotic lesions of coronary arteries, an increase in the content of the inhibitor of plasminogen and antiplasmin in the blood was found, which in turn leads to a significant decrease in anticoagulant activity and inhibition of fibrinolysis. The increased content of Ca2 + ions inside cardiomyocytes in patients of senile age is one of the main pathogenetic factors of myocardial lcontractility in conditions of hypoxia and ischemia. Under observation for 8 weeks were 42 patients (29 of them men and 13 women), their average age was 76.5 ± 2.1 years with a duration of coronary heart disease of 15.1 ± 0.4 years. Group 1 were consisted of patients with coronary artery disease without a history of myocardial infarction, and group 2 – 19 patients, transferred MI from 2006 to 2016. Also, all patients received standard antianginal therapy before the study, and patients from the 2nd group additionally combined cardiometabolic therapy. After treatment, there was an increase in intracellular Ca with a decrease in the concentration of its ionized pool, the normalization of the parameters of calcium homeostasis and fibrinolysis in the process of cardiocytoprotective therapy. However, in the group of patients who underwent MI 8-week therapy is not enough for significant changes in the studied indicators.