Research objective is the comparative analysis of the intraoperative criteria and indicators for early postoperative period of gas-free laparoscopic radical prostatectomy and laparoscopic radical prostatectomy. Gas-free or lifting laparoscopy is a method of surgical treatment in the increased volume conditions in abdominal cavity formed by a mechanical laparolifting without application for this purpose of gaseous or liquid environments. 67 patients with prostate cancer at the age of 62,7 ± 3,7 years are operated in urology clinic Pavlov First Saint Petersburg State Medical University from 2009 to 2015. A total of 67 operated patients with prostate cancer, from them 35 (58%) patients operated laparoscopic radical prostatectomy and 32 (48%) patient using the technique gas-free laparoscopic radical prostatectomy. It is revealed, that when using the technique of gas-free laparoscopic radical prostatectomy compared to laparoscopic radical prostatectomy reliably reduces the volume of blood loss, duration of the o peration, the amount of CО2 consumed and minute volume ventilation, as well as in patients after decreases the duration of hospitalization and the incidence of postoperative complications. Also, the use of gas-free laparoscopic radical prostatectomy allows to completely avoid hypercarbia and respiratory acidosis